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Genetic variation in the GLP1R gene (rs6923761), GIPR receptor pathway (rs1800437), and appetite-regulation genes like FTO (rs9939609) and MC4R (rs17782313) influence individual response rates and side effect tolerance

Although the mechanisms leading to a blood pressure decrease during the treatment with GLP-1 agonists have not been fully elucidated it could be the result of an increased sodium and water excretion and/or inhibition of the RAAS activity 14

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One study of the GLP-1 raising effects of the Mediterranean diet demonstrated a peak GLP-1 level of approximately 59 picograms per millilitre of blood serum

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