baseline and placebo, and YKL-40, ICAM-1, and leptin vs
These early changes show the medication is working, even before weight loss appears
Quick Answer: Feeling cold on GLP-1 medications results from physiological changes during weight loss, including reduced insulating fat tissue, decreased caloric intake lowering heat production, and metabolic adaptations that make the body more energy-efficient
All weight loss leads to both fat and muscle loss, which can be a concern, especially in people who are already frail
Research suggests that a meaningful portion of weight lost on GLP-1 medications may come from lean mass, not just fat
Individual results vary based on factors like starting weight, adherence to the protocol, diet, and exercise habits