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As estrogen levels rise, it triggers the release of luteinizing hormone (LH), which stimulates ovulation
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Most users notice improved hydration and skin texture during this phase, but significant wrinkle reduction remains limited
Modulates expression of genes involved in collagen synthesis, tissue remodeling, angiogenesis, and antioxidant defense, particularly in skin and connective tissue
Long-term maintenance therapy is usually necessary to sustain weight loss benefits
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