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Sensitivity Analysis and Meta-regression Analyses Intertrial heterogeneity was detected across the studies for HbA1c change

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Expected timeline: Week 1-4: Inflammation reduction, potential nerve symptom improvement Week 4-8: Progressive healing, reduced radicular symptoms Week 8-12: Structural improvements developing, continued symptom reduction Week 12-16: Consolidation of gains, assessment for continued protocol Important notes: Disc herniations vary enormously in severity

In addition, the concentration of 5MTHF in the CSF is lower than normal in patients with idiopathic cerebral folate deficiency, and some patients also have reduced concentrations of CSF 5-hydroxyindoleacetic acid and biopterin

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