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In addition, increased ROS production may be generated by mechanical stimuli on the vascular wall, which increase with hypertension

However, it appears to achieve this through more targeted, pro-healing pathways rather than the broad suppression of prostaglandins seen with NSAIDs like ibuprofen

The deficiency most often goes unrecognised because the clinical manifestations are highly variable, often subtle and non-specific, but if left undiagnosed the consequences can be serious

Genes 12 , 1437 (2021)

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