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Study Results Among the 393,596 participants in the NIHs All of Us Research Program with available electronic health records, 20,768 participants had at least one recorded GLP-1RA exposure, while 15,447 participants had two or more records on separate days

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Serious adverse effects requiring medical attention include: Severe, persistent abdominal pain radiating to the back, potentially indicating pancreatitis (seek urgent same-day medical care or call NHS 111

While several gut hormones secreted by intestinal enteroendocrine cells may contribute to the gut-kidney axis, studies have shown that an oral sodium load can increase endogenous GLP-1 concentrations (18)