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What is missing There is no published human pharmacokinetic study of subcutaneous AOD-9604, no published human topical or intranasal exposure data, no Phase 3 efficacy trial, no long-term safety data beyond 24 weeks, and no published human cartilage or joint outcome data

This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only

This non-surgical device is much less invasive than surgery

A 2019 study in malabsorption syndrome confirmed sublingual forms raised levels 2x faster than oral cyanocobalamin