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Physicians will need to pay close attention to the unanticipated emergence of both negative and positive effects seen in patients that may remain on these agents for decades

* The results were based on an open-label 100-person human study conducted over six months with no caloric restrictions or exercise requirements

A meta-analysis of four observational studies, following a total of 7,475 older individuals for 3 to 16 years, found a weak association between an elevation in vitamin B 12 of 50 pmol/L in blood and a reduction in fracture risk (114)

This is especially true if your baseline pressure is already well-controlled or borderline low

Most side effects, if they occur, are mild and temporary