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The density indicates some flexibility at R471 in both the inward-facing and ipratropium-bound structures, but both are pointing down towards the extracellular side and wedged between S157 and S467, preventing the H-bond network we observe in the occluded conformation (Fig

10.1038/nrendo.2017.151 Summary Keywords cost-effectiveness, semaglutide, GLP-1 receptor agonists, type 2 diabetes, China Citation Feng Z, Tong WK, Zhang X and Tang Z (2023) Cost-effectiveness analysis of once-daily oral semaglutide versus placebo and subcutaneous glucagon-like peptide-1 receptor agonists added to insulin in patients with type 2 diabetes in China

doi: 10.3389/fphar.2025.1618079 Received 28 April 2025 Accepted 08 July 2025 Published 24 July 2025 Volume 16 - 2025 Edited by Karuna Rasineni, University of Nebraska Medical Center, United States Reviewed by Yang Yang, Chinese PLA General Hospital, China Asher Rajkumar Rajan, University of Nebraska Medical Center, United States Updates Copyright 2025 Xie, Yang, Tian and Chen

It delineates the dynamics of peripheralization in small suburban towns on one hand, and on the other, it investigates the role of government decision-making, planning instruments, and the interactions among multiple stakeholders

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