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For example, Immunis Inc is developing IMM01-STEM for sarcopenic obesity 69 and Biophytis SA has progressed BIO101 (20-hydroxyecdysone) through a Phase I clinical trial 70 for age-related sarcopenia, including sarcopenic obesity

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These changes lead to an overall increased permeability of the BBB and imbalance of the CNS microenvironment, as well as the potential introduction of pathogens and neurotoxins into the brain that can contribute to neurodegenerative processes (Funk et al., 2021

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