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Thioredoxin reductase (TrxR) from the Gram-positive bacterial antioxidant thioredoxin system has emerged from multiple screening efforts as a potential target for auranofin, ebselen, shikonin, and allicin

In comparison, phenformin showed much less impairment of cell growth with a CC 50 of 2060 M in Calu-3 and 1313 M in Huh7.5 cells (Fig

[DOI] [PubMed] [Google Scholar] 93.Mignani S., El Brahmi N., El Kazzouli S., Eloy L., Courilleau D., Caron J., Bousmina M.M., Caminade A.M., Cresteil T., Majoral J.P

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Efficacy of low-dose methotrexate in rheumatoid arthritis