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A phase 3 study was terminated for lack of efficacy (ClinicalTrials.gov Identifier: NCT00294541) ( N -Methyl D-aspartate receptors (NMDARs) are non-selective calcium channels present in erythroid precursors and circulating RBCs and have been shown to be abnormally increased in RBCs of patients with SCD ( in vitro and to reduce sickling in the setting of deoxygenation

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Steroid pregnenolone sulfate enhances NMDA-receptor-independent long-term potentiation at hippocampal CA1 synapses: role for L-type calcium channels and sigma-receptors