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Preclinical studies included in the review showed the following actions of GLP-1 analogs in psoriasis: decrease in interferon-gamma and interleukin-4 in a dose-dependent manner decrease in interleukin-6, tumor necrosis factor-alpha, and lipopolysaccharide-induced inflammation reduction in keratinocyte proliferation and macrophage migration The review also included human data to determine whether GLP-1 analogs have a role in treating inflammatory arthritis and psoriasis

Weight gain can happen for a few reasons: Hormone changes : Lower estrogen levels can lead to more belly fat storage

Phillips, H

doi:10.1002/14651858.cd009591.pub2

Improve Body Composition: Research into metabolic health and fat loss might benefit from this combination, as GH influences lipid metabolism