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Exendin-4, a stable synthetic form of GLP-1, is commonly used clinically for diabetes treatment because GLP-1 has a short half-life (Heppner et al., 2015b)

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Semaglutide 2.4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2)

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Small-molecule inhibitors targeting these pathways have been developed, but their clinical translation has been met with challenges related to toxicity, incomplete CSC eradication, and the emergence of compensatory resistance mechanisms

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