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Methionine is an essential amino acid that increases metabolism

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targeted NNMT knockdown protected against DIO by increasing energy expenditure

The use of NNMT inhibitors as a potential obesity treatment has been investigated preclinically 8,9,13 , and observational clinical data suggests that increased NNMT expression and activity correlate with increased incidence of Type 2 diabetes (T2D) and risk of obesity, respectively 10,11