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Concurrently, the same pool of NADPH fuels the GPX4, thioredoxin reductase, and lipid-remodeling pathways, both neutralizing peroxides and synthesizing protective phospholipids (PUFA-OHs) to counteract ferroptosis

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12.2 Curcumin and chemotherapeutic agents The interaction between curcumin and chemotherapeutic agents is more complex and can be either beneficial or detrimental, depending on the specific chemotherapy drug and cancer type (243)