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The findings were summarized using the GRADEPro GDT v.4 software (McMaster University, ON, Canada), and include all the results on all-cause mortality and changes in HbA1c, FPG, BMI, SBP, GFR, and total cholesterol levels

At the in vitro level, cellular modelsincluding primary neuronal and microglial cultures, immortalized lines such as SHSY5Y (a human neuroblastoma cell line), 64 , 65 , 66 and BV2 (a murine microglial cell line), 67 and human induced pluripotent stem cell (iPSC)derived brain organoids 68 offer tractable systems for mechanistic dissection and pharmacological screening under controlled conditions

Mitochondria and PGC-1 in aging and age-associated diseases

W., Wilson, K

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Uterine fibroids: the elephant in the room