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GLP-1, a product of the glucagon gene, is produced in L-cells of the small intestine
Once weekly (OW) semaglutide is used as an example to illustrate how the authors might switch to a different GLP1RA in clinical practice
They might also lessen the need for major orthopedic surgery
one common approach began at 0.5 mg once weekly , with incremental increases at approximately four-weekly intervals up to target maintenance doses of 4 mg, 8 mg, or 12 mg once weekly
Some report increased energy (possibly from glucagon), others report fatigue GI tolerance: Wide variability
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