Furthermore, H&E staining showed that compared to the aorta of normal aging mice, the aorta of mice treated with FOXO4-DRI was thinner, and the PWV value was lower in the ultrasound detection results, which means that the mice treated with FOXO4-DRI had better vascular elasticity and better vascular function than normal aging mice (Figures 1D,E)
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One possible mechanism
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The molecule, called BRP (short for BRINP2-related peptide), reduced food intake and body weight in mice and pigs without producing several of the adverse effects associated with existing weight-loss medications