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(5) Increased cardiomyocyte contractilityRestoring cardiac contractility and pumping efficiency is a key target of gene therapy, particularly through SERCA2a and its regulatory proteins, which modulate intracellular Ca dynamics to alleviate symptoms in patients with HFrEF and improve long-term outcomes (Fig

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Ultraestructuralmente, se observa numerosos melanosomas en estadio III y IV agrupados dentro de los queratinocitos basales y melanfagos papilares drmicos

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