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Cardiovascular risk factor improvements (blood pressure, lipids, HbA1c) Any unexpected side effects at longer treatment durations If VANQUISH-1 results confirm 20%+ weight loss with favorable tolerability, VK2735 becomes one of the most compelling obesity drugs in the pipeline not because it beats retatrutide, but because it offers a meaningful step up from tirzepatide with potentially better tolerability

The temptation is real, and the FDA has data on what happens when patients give in

stay hydrated and monitor symptoms closely before making any changes

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E., et al., Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease

Stay Extremely Well-Hydrated: Combat dry mouth by drinking water consistently throughout the day