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Moreover, 3-mercaptopyruvate sulfurtransferase generates both LMW and protein-bound supersulfides via the transsulfuration pathway (22, 23)

Because understanding these mechanisms opens the door to smarter strategies: Targeted GST inhibitors Prodrugs designed to bypass resistance Therapies that re-sensitize tumors to treatment This shift from simply attacking cancer cells to strategically disarming their defenses could redefine how we approach treatment-resistant breast cancer

Available from: Higuchi T, Connors K

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Cysteine is derived from methionine via homocysteine, and its metabolism involves complex interactions with various enzymes, cofactors, and regulatory molecules