Liraglutide si lega ai recettori del GLP-1 a livello centrale (ipotalamo) e periferico, mimando gli effetti del GLP-1 fisiologico con unemivita pi lunga
Pandey S, Subramanaym Reddy C, Yaqoob U, Negi YK, Arora S (2015) Insilico analysis of cis acting regulatory elements CAREs in upstream regions of Ascorbate Glutathione Pathway Genes from Oryza sativa
It consisting of: An extracellular N-terminus that binds the C-terminal part of the incretin analog A seven transmembrane helical domain (TMD) with the a-helices separated by three intracellular loops and three extracellular loops An intracellular C-terminus that is responsible for signaling The EM structure of Semaglutide bound to the complete GLP-1R and G-proteins (Figure 2, PDB ID 7ki0, Zhang et al., 2021) shows some hydrophobic and many specific polar interactions between the peptidic drug and the GLP-1 receptor molecule
Some patients lost up to 25 percent of their body weight
Kruger N et al
This binding triggers the cascade of intracellular events that eventually lead to the activation of the PI3/AKT and MAPT pathways
