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Furthermore, there are drug interactions, particularly noted among online communities like Longecity, against the concurrent use of FOXO4-DRI with certain compounds such as Rapamycin, Quercetin, corticosteroids, and cortisol, due to potential interactions that might diminish the peptide's senolytic efficacy

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In clinics it is used for skin brightening and antioxidant support

Mechanistic Insights into the Multiple Functions of Niacinamide: Therapeutic Implications and Cosmeceutical Applications in Functional Skincare Products