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It is structurally modified to be long acting compared with native amylin and has been studied as a novel signaling compound affecting appetite regulation and energy balance

Your body produces it in the liver and kidneys and stores it in the heart, brain, sperm, and skeletal muscles

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To further investigate the transcriptional changes in functionally coordinated genes, Gene Set Enrichment Analysis (GSEA) 33 was performed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) functional gene sets available in MSigDB ( The top 10 downregulated and 10 upregulated KEGG gene sets in GLA-mutant Fabry kidney organoids compared with WT kidney organoids are shown in Supplementary Table 2