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That gave the background for doing the STEP trials with 2.4 milligrammes of semaglutide per week, with a slow up-titration to avoid problems which eventually resulted in 18 per cent weight loss in the STEP trials

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It was designed by Al-Obeidi, Castrucci, Hadley and Hruby and reported in the Journal of Medicinal Chemistry in 1989, using quenched molecular dynamics simulations to identify which conformation of the alpha-MSH 4-10 message sequence was worth constraining

Therefore, they are not the best model for assessing the effects of supraphysiological GH in otherwise healthy people