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Recent reports elucidated that HSPA5 upregulation negatively regulates ferroptosis in pancreatic cancer, while ATF4 activation upregulates HSPA5, thus the HSPA5-GPX4 pathway is one of the causes of gemcitabine resistance (Zhu S

Bae 2009), and helps preserve renal function in animal models of diabetic nephropathy (Feng 2013)

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A 2023 study comparing various nutritional scores for predicting postoperative complications after neoadjuvant therapy in ESCC found that the predictive efficacy of PNI was superior to most other indicators (98)

Ochratoxin A (OTA): Produced by Aspergillus and Penicillium species, OTA is nephrotoxic (kidney-damaging), immunosuppressive, and has been detected in human blood, breast milk, and urine

Avoid taking the medication too early or doubling up on doses, as this can lead to complications