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Ketamine blocks the NMDA receptors of GABA interneurons, thus suppresses their ability to inhibit pyramidal neurons, thereby induces cortical excitation (11, 177)

The comments and suggestions provided by the anonymous reviewers significantly improved this manuscript and we greatly appreciate their efforts

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If you are concerned about tracking this precisely, a simple log noting when the vial comes out and goes back in can prevent uncertainty

The severity of these effects correlates directly with the amount of alcohol consumed