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In addition, longitudinal monitoring of circulating biomarkers and proteomic signatures could provide a means to assess therapeutic response at the molecular level, enabling more precise and personalized cardiovascular risk stratification

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Emerging therapies, including dual and triple agonists and small-molecule oral formulations, demonstrate how targeting multiple pathways and improving delivery can enhance efficacy and patient convenience

Major weight loss can also cause a shift in nutrient absorption

56 These trials demonstrate that although orforglipron is safe and efficacious more longitudinal research is warranted to provide deeper insights into their efficacy, safety and tolerability before their potential incorporation in the pharmacological arsenal against T2DM or obesity

Inverse relation of body weight and weight change with mortality and morbidity in patients with type 2 diabetes and cardiovascular co-morbidity: an analysis of the PROactive study population