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GH-stimulating peptides (CJC-1295, Ipamorelin, Tesamorelin) should not be combined with exogenous synthetic HGH without medical supervision, as the combined GH elevation can suppress the pituitary's feedback loop and increase the risk of acromegaly-related side effects

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The supernatant was centrifuged at 100,000 g for 60 min at 4 C

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The amidated C-terminal residue differs across CT-family peptides and this residue forms the only direct contact with RAMPs in previously reported AMYR complexes 15,16