Oxidation reactions produce modified peptides with altered or absent biological activity
Beginning with CY 2009 payments, outlier payments are subject to a reconciliation process similar to the IPPS outlier reconciliation process for cost reports, as discussed in the CY 2009 OPPS/ASC final rule with comment period (73 FR 68594 through 68599)
Mechanism of Action Semax is a synthetic heptapeptide analog of ACTH, a hormone
The arginine salt formulation shows only 15.1% degradation after 5 hours at pH 3.0, compared to 99% destruction of standard acetate forms under the same conditions
References Heffernan, M., et al
Koopman M, Daniels JK, Spitzer C, Lampe A, El Aidy S