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Recent studies have identified artesunate, traditionally an antimalarial drug, as a potential therapeutic agent for BL due to its ability to trigger ferroptosis, a specialized form of cell death

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The astrocytic glutamate transporter GLT-1/EAAT2 expression is markedly reduced (Rothstein et al., 1995)

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Due to the distinct position of the conjugated N-terminal lipid between Cagri-CTR and Cagri-AMY 1 R, we also determined a structure of CTR-Gs in complex with an analogue of Cagri that lacked the lipid modification (CagriBB) to interrogate the contribution of the acylation to the conformation of Cagri-CTR complex