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Compared to placebo, semaglutide substantially improved the outcomes of people with metabolic dysfunction associated steatohepatitis (MASH)

It does not affect platelet function or coagulation pathways, so the combination does not inherently increase haemorrhagic complications beyond the baseline risk of anticoagulation therapy alone

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These therapies should be regarded as key components of larger cardiovascular risk reduction strategies, especially for individuals with established heart disease or type 2 diabetes, in addition to being used as treatments for glycaemic control