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Biomolecules , 10 (10), 1429

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Cinchonine ranked first with a high connectivity score (enrichment score=0.911, mean=0.684), suggesting that cinchonine exerted GLP-1R agonist-like effects

The annulus fibrosus forms the outer ring, a complex series of fibrous layers made primarily of type I collagen arranged in alternating diagonal patterns

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Males are more often affected than females and skin types I and II are particularly at risk