Clinical trial data from the SURMOUNT and SURPASS programs did not show dramatic differences in efficacy between abdominal, thigh, and upper arm injections for the majority of participants
During GLP-1R blockade, infusion of glucose was immediately required upon starting GLP-1m infusions in all subjects due to a more dramatic reduction in HGP, as well as a delayed and modest insulinotropic response
She is currently conducting several interventional clinical trials in adolescents with PCOS with the goal of reversing early cardiometabolic disease
However, alcohol complicates GLP-1 therapy in other ways
GLP-1 is deactivated by dipeptidyl peptidase IV (DPP-IV), which cleaves off the two NH2-terminal amino acid residues, transforming the peptide into an antagonist of the GLP-1 receptor
TRIUMPH-5 is the closest active-comparator trial