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As was previously mentioned, ROS formation is induced by A aggregating and cause a number of oxidative damages and metabolic insults including generation of HNE in hippocampal neurons, which could in turn mediate the toxicities of such insults [89]
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Stress and anxiety are also important contributors
TosicMOttJBarralSBovetPDeppenPGheorghitaFet alSchizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene
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