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In contrast, at least 1 of the folate receptors, FR-, is expressed in hematopoietic cells and the kidney proximal tubules, among other tissues (Table 2)

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2017 study reported improvements in aged mice that were sustained through the observation period, suggesting that senescent cell clearance produces durable benefits once senescent cells are eliminated, their pro-inflammatory SASP burden is removed, allowing tissue recovery that persists beyond the treatment window