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Synapse 70(12):479500

Expression of PML-RAR in APL cells is associated with induction of leptin receptor (OB-R): Putative role of mesenchymal stem cell derived-adipocytes in survival of APL cells

According to the company, GEP-44 produced meaningful reductions in food intake and body weight while also improving glycemic control in preclinical studies

Although the extent to which uric acid reduction contributed to the regression in hepatic steatosis is unclear, it likely had at least an additive effect, wrote Zeybel

Committee discussion focused on next steps and implementation: members asked that the advisory council analyze historical claims and utilization data, estimate potential cost savings from preventive care and treatment, recommend consistent treatment models across managed-care organizations, and consider equity issues for rural and tribal communities where access and nutrition options may be limited

Although this data analysis was performed in late 2024, there are some well-proven clinical benefits of GLP-1 medications which the researchers did not include in this model