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"The rodent data is compelling but cannot substitute for proper clinical development" 14

Usually for injection is 1000bottles, oral solution is 1000L, powder or granule is 100kg

It was withdrawn during phase 3 due to heart failure problems, but is still in clinical development for alternative indications

doi: 10.1007/s10787-017-0356-x [DOI] [PubMed] [Google Scholar] 268.Yuan K, Zhu Q, Lu Q, et al

These are all valid approaches, each with its own set of advantages and drawbacks

Acting on the gastrointestinal tract Gastrointestinal reactions are the most common adverse reactions of GLP1 capsules, and their mechanism of occurrence is closely related to the widespread distribution of GLP1 receptors in the gastrointestinal tract