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Researchers are expected to operate within their own institutional ethics, Control of Substances Hazardous to Health (COSHH), and biosafety frameworks

To assess the impact of post-randomization changes in metformin use, two sensitivity analyses were conducted for the CV outcomes: (1) censoring for initiation and discontinuation of metformin during the study using the Cox proportional hazards model described above

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10.3389/fphar.2021.667753 [DOI] [PMC free article] [PubMed] [Google Scholar] 189.Halperin Kuhns, V

Research on Tirzepatide (the dual agonist predecessor) showed that participants retained 75% of weight loss from fat mass rather than lean mass