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Summary: True vitamin B12 overdose is exceptionally rare because it is water-soluble and excess amounts are excreted through urine rather than accumulating in body tissues

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Subepithelial myofibroblasts expressing GLP-2R increase IGF-1 mRNA expression and secretion in response to GLP-2 stimulation, and genetic deletion of the intestinal epithelial IGF-1 receptor abolishes GLP-2-induced crypt cell proliferation in mice (69, 70)

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