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Aggressive dose escalation may produce faster initial weight loss but often leads to intolerable symptoms that force users to stop treatment entirely

The improvements require ongoing treatment to maintain

Additionally, some studies suggest that GLP-1 receptor agonists may increase energy expenditure, possibly by enhancing thermogenesis in brown adipose tissue [57]

Virchows Arch (2014) 465(1):2533

It may be suitable for patients needing significant weight loss or those unresponsive to previous treatments

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