Elife 8 , e40092 (2019)
Clinicians frequently recommend stepping down doses and holding each lower dose for two to four weeks while monitoring weight and glucose, because benefits usually accumulate over months, with roughly 70% of patients achieving significant weight loss after six months
Further, T2DM remains one of the most significant risk factors not only for the development of MASLD but also for the progression of liver fibrosis and the occurrence of liverrelated complications, including HCC (Hosseinkhan et al., 2025
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