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Montastruc JL, Sommet A, Bagheri H, Lapeyre-Mestre M

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RESULTS Cancer cells maintain viability and proliferation in the absence of ACLY and exogenous acetate Since cancer cells are adept at engaging available metabolic flexibility mechanisms, we hypothesized that non-canonical acetyl-CoA production mechanisms could be revealed by developing ACLY KO cancer cell models that are not dependent on acetate for viability