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Theriogenology (2000) 54:77186

For instance, closed comedones, or whiteheads, occur when the hair follicle is completely blocked, while open comedones, or blackheads, form when the blockage is exposed to air, causing it to oxidize and turn dark

A prominent example of a specific mutation associated with obesity was the discovery that a four base-pair deletion in the melanocortin-4 receptor (MC4R) leads to obesity by inhibiting the leptin-melanocortin pathway [11]

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