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Replace roller after the recommended number of applications per manufacturer guidelines
Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
Deciding which peptide is best for weight loss
For type 2 diabetes management (as opposed to weight loss alone), semaglutide is also marketed as Ozempic at a maximum dose of 2.0 mg weekly
If you experience progressive neurological symptoms (numbness, tingling, difficulty walking), cognitive changes, or severe anaemia, seek urgent GP assessment
One non-prescription option gaining attention for evidence-backed metabolic support is Motus by Tonum (oral)
