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Importantly, the increase in threshold already is present in well controlled (A1c = 6.5%) T2DM patients and increases progressively with increasing A1c

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In studies simultaneously investigating concentrations in different specimen, a preferential distribution of individual compounds has been observed, e.g., of ferulic acid and 5-(3,4-dihydroxyphenyl)--valerolactone into synovial fluid compared to serum

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