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Collecting duct water permeability inhibition by EGF is associated with decreased cAMP, PKA activity, and AQP2 phosphorylation at Ser(269)

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Broad interest is now focused on the biguanide metformin 37, 38 (see review in the same issue of this topical issue) as well as IR and IGF-1R inhibitors

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Yamada T, Nakamura S, Demitsu T, Nakamura T, Iida E, Yoneda K, Fukuda S, Hashimoto T (2013) Paraneoplastic pemphigus mimicking toxic epidermal necrolysis associated with B-cell lymphoma