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This finding supports the hypothesis that high intake of iron along with ascorbic acid could increase in vivo lipid peroxidation of LDL and therefore could increase risk of atherosclerosis [51]

740,741 It is worth noting that SLC7A11/xCT-mediated cystine uptake is a double-edged sword in cellular oxidative regulation

Therefore, future trial designs must prioritize both the implementation of objective neurophysiological biomarkers and the adoption of extended follow-up schedules to comprehensively evaluate the true therapeutic potential and disease-modifying capacity of novel interventions for tinnitus

The success rate from first-in-human to registration for neuroactive drugs targeting the CNS is significantly lower than for other indications, such as cardiovascular, infectious, inflammatory, and metabolic diseases 3,4

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This is because it takes time for the new, brighter skin cells to move from the deeper layers to the surface