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GLP-1 weight loss drugs have quickly moved from medical journals to household conversations, reshaping how Americans think about obesity, diabetes and weight loss

One may appear skinny fat, with low muscle and poorer metabolic health, while the other carries more muscle, burns more calories at rest, and moves with more stability

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Semaglutide (marketed under the brand name Wegovy) and liraglutide (Saxenda) did lead to weight loss, but it was significantly less at 15% and 8%, respectively

These molecules act as signals that stimulate intestinal cells to release GLP-1

However, whether these effects are mediated through GLP-1 or GIP pathways remains unclear